Screen compound libraries and prioritize compounds for testing.MembranePlus has several primary applications: Simulation of in vitro permeability & hepatocyte concentrations The MembranePlus permeability modeling platform has been utilized by companies across various industries and departments since 2014. CROs which provide in vitro permeability (Caco-2, PAMPA, or MDCK) or hepatocyte services, to assist with the optimization of the experimental design for client studies.Users of GastroPlus™ looking to better inform inputs (e.g., lysosomal trapping, diffusional clearances, biliary excretion) for more accurate in vivo absorption and systemic clearance/distribution predictions with the Advanced Compartmental Absorption and Transit (ACAT™) and PBPK modelsĭiscovery scientists looking to categorize compounds into high and low permeability classesĭMPK researchers that focus on in vitro transporter/metabolism kinetic studies – model your measured data to capture all relevant information from the expensive experiments you are running Unfortunately, these experiments are expensive, and since you don’t have a lot of time or material available, how do you prioritize which compounds to test early in your project? Once you have identified a few promising leads, is your experimental design robust enough to capture all of the relevant information you need? And, after you collect the data and compile your apparent permeability or intrinsic clearance, are you certain you are not overlooking anything?Įnter MembranePlus™, the industry’s leading mechanistic in vitro permeability & hepatocyte modeling software. Your modeling tool for IVIVE of absorption and systemic clearance/distribution processes…įor over 20 years, significant research has been devoted to in vitro permeability (e.g., Caco-2 assays) and hepatocyte systems, with several guidelines being published and all pharmacopeia describing appropriate methods for testing.
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